Antimicrobial resistance is a global concern as new mechanisms of resistance are emerging and spreading globally, threatening our ability to treat common infectious diseases, resulting in prolonged illness, disability and even death. The study was focused on comparing the effectiveness of amoxicillin alone and amoxicillin with clavulanate potassium in combination by checking the sensitivity/resistance pattern of clinical isolates of Staphylococcus aureus and Escherichia coli respectively. S. aureus NCIM 5021 and E.coli NCIM 2118 were used as reference strains in the study. All the strains were subjected to susceptibility test by agar-well diffusion method and the resistance/sensitivity pattern was interpreted as per NCCLS guidelines.
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